Please use this identifier to cite or link to this item: http://hdl.handle.net/10790/5509

Lipophilicity Determination of Energy-Enhancing, Nootropic Supplements

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Title:Lipophilicity Determination of Energy-Enhancing, Nootropic Supplements
Authors:Le, Diana
Morimoto, Pashyn
Ashburn, Bradley O.
Contributors:Ashburn, Bradley O. (instructor)
Date Issued:2020
Publisher:Native Science Report
Citation:Le, D., Morimoto, P., & Ashburn, B. O. (2020). Lipophilicity Determination of Energy-Enhancing, Nootropic Supplements. Native Science Report. Retrieved from https://nativesciencereport.org/2020/11/lipophilicity-determination-of-energy-enhancing-nootropic-supplements/#more-5961
Relation:https://nativesciencereport.org/2020/11/lipophilicity-determination-of-energy-enhancing-nootropic-supplements/#more-5961
Abstract:Nutritional supplements comprised a $123 billion industry globally in 2019 with energy and cognitive enhancement products constituting a quarter of that amount. However, these products are not regulated by the Food and Drug Administration (FDA) and manufacturers typically make bold, unsubstantiated claims of product efficacy. Unbiased, neutral-party evaluation is vital for public health safety. The goal of this study was to model the absorption of three energy-enhancing, nootropics (caffeine (1), theacrine (2), and methylliberine (3)) through the use of an octanol/water mixed solvent system and UV-Vis spectrophotometry to determine their lipophilicity. The measure of a molecule’s lipophilicity is a valuable pharmacological and toxicological property which is used to determine how well a molecule is absorbed through cellular membranes from extracellular fluid into the cell. Standard curves of known concentrations were created using serial dilution to enable analysis of the unknown concentration after partitioning. The resulting values were replicated by duplicate trials for validation of reproducibility.
Pages/Duration:12 pages
URI:http://hdl.handle.net/10790/5509
Rights:Attribution-NonCommercial-NoDerivs 3.0 United States
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Journal:Native Science Report
Appears in Collections: Le, Diana
Morimoto, Pashyn
Ashburn, Bradley O.


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