DKICP Student Research Projects

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Comparative effectiveness of the A.L.O.H.A. project didactic training versus the integrated mixture of the didactic and experiential training programs on knowledge, confidence, and empathy of students enrolled in doctor of pharmacy program.
(2017-04-06) Jose, Abraham C.; Mizusawa, Kelsea A.; Mow, Lauryn P.; Gomez, Lara; Wongwiwatthananukit, Supakit
Effective pharmaceutical care includes components of knowledge, skills, confidence, and empathy, which are utilized throughout the wellness screening and consultation process. The organization puts its members through training that focuses on proper screening techniques, knowledge of common disease states, and development of effective communication through counseling with patients. Our mission fits into the CAPE Educational Outcomes in promoting health improvement, wellness, and disease prevention for individuals and communities (promoter) and educating patients and communities (educator).
Evaluation of antioxidant and anti-cancer activities of Fucose-containing sulfated polysaccharide (FCSPs) from Hawaiian Marine Algae
(2018-04-03) Fukuchi, Ashley; Sang-ngern, Mayuramas; Sunada, Nathan; Phosri, Santi; Tan, Ghee Teng; Chang, Leng Chee
Fucoidan is a group of sulfated polysaccharides isolated from marine algae. Fucoidan exhibits a variety of biological activities which are related to their chemically distinct sulfated fucose backbone. The structures of select fucoidans vary by species, and the structure and bioactivity remains unclear. The fucoidan of Padina sp., Asparagopsis taxiformus, and Nishime Kombu were extracted using four different methods using water at different temperatures. Method 2 gave the highest yield of fucoidan by 1H NMR analysis, whereas method 4 yielded FCSPs with anti-cancer activities. The crude fucoidan of Padina sp. was further purified using ion-exchange chromatography, resulting in the highest yield of fucoidan at 2.5 M NaCl. Cell viability was determined using sulforhodamine B (SRB) assay in five cancer cells (LNCap, PC-3, MCF-7, Caco-2, and LU-1). Both standard and Kombu-extracted fucoidan showed no effects on prostate (LNCaP and PC-3), and breast (MCF-7) cancer cells, but inhibited the growth of colon (Caco-2) and lung (LU-1) cancer cells by 43-74% at concentrations in the range of 50-400 µg/mL. These crude FCSPs also exhibited antioxidant activity. The FRAP values of Nishime Kombu, U-Fn, and Fucoidan Force, were 586.44 ± 107 µM/mg extract, 2922.38 ± 981 µM/mg, and 4212.03 ± 745 µM/mg, respectively.
Evaluation of Patients Knowledge of Medicare Part D Plan Annual Assessment in a Family Medicine Clinic
(2018-04-10) Hino, Garret; Prudencio, Jarred; Prudencio, Jarred
The Hawaii Island Family Health Center (HIFHC) is a family medicine clinic affiliated with Hilo Medical Center. HIFHC serves as a primary care training program site for medical residents, pharmacy students, nursing students and psychology fellows. Pharmacy services at HIFHC focus on comprehensive medication management, chronic disease state management, drug information consults,and medication access assistance. The objective was designed to assess patient's knowledge regarding open enrollment and their ability to annually reassess Medicare Part D to determine if appointments with a clinical pharmacist should be offered during open enrollment.
Implementation of a Health Screening Training Process for Second and Third Year Pharmacy Students
(2018-04-10) Paulachak, Kara; Chavez, Rene; Kim, Michelle; Prudencio, Jarred; Kim, Michelle; Prudencio, Jarred
Student pharmacists at the Daniel K. Inouye College of Pharmacy (DKICP) at the University of Hawaii at Hilo frequently participate in community health screening events led by various student organizations. The objective of this study was to evaluate student retention of knowledge of counseling points regarding common community disease states after a standardized health screening training process, measured by a change in scores of a multiple-choice assessment. This study was to assess how effective this training was based on student knowledge retained over the course of the academic year.
Innovative hyperlidipemia screening protocol focusing on 10-year risk of atherosclerotic cardiovascular disease
(2018-04-10) Nakagawa, Christopher; Rhee, Caroline J.; Tran, Vivian L.; Prudencio, Jarred B.; Prudencio, Jarred
Daniel K. Inouye College of Pharmacy's previous hyperlipidemia screening protocol focused on a patient's specific total cholesterol. The objective was to create a screening protocol that incorporates the patient's 10 year atherosclerotic cardiovascular disease (ASCVD) risk score to reflect the 2013 American College of Cardiology (ACC)/American Hear Association (AHA) cholesterol guideline.
Medicare Part D prescribing changes of tricyclic antidepressants between 2013 and 2014
(2017-04-11) So, Nadine W.; Taira, Deborah
Tricyclic antidepressants were the primary pharmacologic treatment for depression in the United States from the 1960s to the late 1980s. Since then, other classes of antidepressants, such as Selective Serotonin Reuptake Inhibitors, have replaced its use as first-line agents due to their more favorable side-effect profile and proven equal efficacy. Tricyclic antidepressants are included in the Beers Criteria because of their potentially harmful side effects in the elderly (e.g. cognitive impairment, delirium, sedation, and orthostatic hypotension). The purpose of this study is to evaluate the changes in prescribing of tricyclic antidepressants from 2013 to 2014 in Medicare beneficiaries.

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